The Global Commission on Drug Policy and WHO co-organized the Inter-Ministerial Dialogue “Catalyzing Action on Drug Policy: Promoting Health-Based Responses at National Level through UN System Collaboration” on the margins of the 78th World Health Assembly (WHA). Moderated by Commissioner Michel Kazatchkine, speakers included Helen Clark (GCDP), Justice Tettey (UNODC), Mandeep Dhaliwal (UNDP), Álvaro Ayala Meléndez (Colombia), Francisco Pavão (Portugal), Neil Gray (Scotland), and Jérôme Salomon (WHO). Discussions highlighted alignment with the UN System Common Position and International Guidelines on Human Rights and Drug Policy, with participants underscoring reforms, national experiences, and the need for stronger UN system collaboration.