A new special collection brings together diverse perspectives on harm reduction across Europe, examining its history, current challenges, and future directions. Contributions from policymakers, researchers, practitioners, and people with living and lived experience of drug use highlight both progress and persistent gaps, particularly in Eastern and Southeastern Europe and Central Asia. The series includes an article, “Europe Must Continue to Lead on Harm Reduction” by Commissioner Michel Kazatchkine and Brendan Kahn (Advocacy Coordinator, GCDP), underscoring the need for political will to expand lifesaving services and adapt to an increasingly complex drug situation.