This report outlines essential actions for sustaining the HIV response among people who use drugs (PWUD). It calls for integration of harm reduction services into health systems, inclusion in universal health coverage, legal protections for confidentiality, and elimination of discrimination. The report highlights the need for dedicated and transparent financing, including domestic and donor support, and for the meaningful involvement of community-led organizations in policy development, service delivery, and monitoring. It also emphasizes the importance of incorporating these elements into national sustainability roadmaps and the next Global AIDS Strategy to support long-term, inclusive HIV responses.